December 
                2006 - January 2007
              
               1. PAN Europe activities
             
              
              
               PAN Europe and Health and Environment alliance organise 
              workshop in the European Parliament
              On the 7 of March, PAN Europe and Health and Environment 
              Alliance (HEAL), hosted by Green MEP Hiltrud Breyer, will organise 
              an event in the European Parliament (EP) to highlight legislative 
              measures necessary to protect children against pesticides. The event, 
              part of a joint campaign of PAN and HEAL, will focus on the vulnerability 
              of children to pesticides and will call for stringent measures under 
              the new Regulation for placing pesticides in the market. The workshop 
              will have as speakers independent researchers and scientists laying 
              out the science behind the vulnerability of children to pesticides, 
              the effects of substances with neurotoxic effects and the lack of 
              protection against residues commonly present in food. The presentations 
              will be followed by a roundtable where scientists will be able to 
              answer the questions from the audience.
                        
            New PAN Europe review on the state of the art of IPM 
              and organic systems in potato production in Europe
              Despite pesticides currently used in conventional potato production 
              in Europe having serious health and environmental hazards, the extent 
              of organic production is still very small. Organic potato producers 
              face some difficulties in terms of dealing with adequate plant nutrients, 
              especially nitrogen application; weed, insect and disease control 
              issues and marketing issues but their profit margins seem to be 
              equal or higher to conventional farmers due to the higher market 
              price of organic potatoes. 
            As for IPM, there are no figures for the extent of certified IPM 
              potato production in Europe, although there are several standards 
              being used in different countries. A holistic view, prevention, 
              correct cultivation techniques, existence of systems for early warning 
              and advice and preference of non-chemical crop protection are components 
              in successful IPM systems and should be extended to all potato production 
              systems in Europe. This new report reviews pesticide use in potato, 
              techniques avoiding or reducing pesticide use and opportunities 
              and constraints for their wider adoption in Europe. 
             
            Insecticides threaten Europe’s Bees 
              
              The bee-keeping industry has suffered heavy annual losses over the 
              past decade in numerous countries, in Europe and elsewhere. The 
              suspected culprit is the use of new insecticides. These products 
              are systemic (contaminate the entire plant including pollen), persistent 
              and have chronic, or long-term, effect, poisoning bees and altering 
              their behaviour, resulting in the rapid death of the hive. One of 
              the active substances which have been blamed for this outcome is 
              fipronil, which is currently being used under provisional authorisation. 
              The EU authorities are currently examining the possibility of including 
              it on their ‘positive’ list of substances (under the 
              Pesticides Authorisation Directive 91/414), which Member States 
              may then authorise. 
            A committee of experts whose advice is key to the authorisation 
              process, the Standing Committee on the Food Chain & Animal Health 
              (which assists the Commission), is visibly wavering between simply 
              banning this substance, and choosing an as-yet unspecified ‘flexible’ 
              solution, which would leave EU Member States a veritable hot potato 
              to handle. The decision to approve or ban fipronil was again postponed 
              in the meetings of December 2006 and January 2007. 
            The stakes are high. On one hand, fipronil earns its manufacturer, 
              BASF, an annual income of several hundreds of million euros. But 
              on the other hand, apart from honey and pollen production, the bee-keeping 
              industry also represents the economic value of pollination to agriculture 
              (worth some US$200bn worldwide each year, according to the Food 
              & Agriculture Organisation). What is more, by contributing to 
              the economic welfare of many small growers, bee-keeping backs up 
              policies which are struggling to curb loss of rural livelihoods, 
              which is a challenge in several European countries. General environmental 
              interests are also on this side of the equation, since fipronil, 
              a persistent product, which is toxic even in small doses, ends up 
              accumulating in surface water and the air, where its presence is 
              beginning to cause concern. 
            PAN, joined by bee-keepers and several environmental groups have 
              been jointly calling for the Commission and the Member States experts 
              to ban fipronil and other insecticides of concern for bees. They 
              are also demanding that a system be put in place to evaluate the 
              risks associated with pesticides, also taking into account the chronic 
              effects of poisoning, analysis of which is not currently done. They 
              point out that the beehive, a complex organism which, along with 
              nectar gathering, does an extraordinary job of micro-sampling and 
              thus provides a vital advance warning system for our environment. 
              
              
            
              2. Published news and information            
            Approval of active ingredients in EU review 
              The EU Standing Committee on the Food Chain and Animal Health (SCFCAH), 
              in its meeting of 22-23 January has postponed the decision on the 
              following substances: pirimiphos-methyl (cholinesterase inhibitor), 
              ethoprophos (cholinesterase inhibitor, acute toxic, carcinogen, 
              potential groundwater contaminant), 1,3 – dichloropropene 
              (acute toxic, carcinogen, groundwater contaminant), fipronil (toxic 
              to bees), methomyl (cholinesterase inhibitor, acute toxic, suspected 
              endocrine disruptor, potential groundwater contaminant), benfuracarb 
              (cholinesterase inhibitor), trifluralin, azoxystrobin, imazalil 
              (carcinogen, reproductive toxin), kresoxim-methyl (carcinogen, potential 
              groundwater contaminant), spiroxamin, azimsulfuron, prohexadion-calcium 
              and fluroxypyr.
              
            Court case in France recognises Parkinson’s as 
              a professional disease caused by neurotoxic pesticides
              In October 2006, a Court judging social affairs in Bourges has recognized 
              Parkinson’s as an occupational disease, following a complaint 
              from a retired agriculture worker suffering from the disease since 
              1997. It is the first time such a decision is taken by a Court, 
              since Parkinson’s is not among the official list of diseases 
              considered as occupational.
            Although the decision will not influence other court cases, it 
              has serious consequences for employers who can no longer ignore 
              the importance of communicating and preventing the risks of neurotoxic 
              pesticides. The risk of contracting Parkinson’s is multiplied 
              by two in the case of exposure to neurotoxic pesticides, says Jean-Luc 
              Dupupet, doctor from Caisse Centrale from Mutualité Sociale 
              Agricole. He supports his claim in numerous scientific studies recently 
              published. An epidemiological study conducted in France between 
              1999 and 2001 and entitled “Terre” concludes that the 
              risk of developing Parkinson’s is multiplied by 1.9 when there 
              is contact with pesticides or in the case of agriculture workers. 
              A review of 19 studies about the disease concluded that the risk 
              of developing Parkinson’s is multiplied by 1.9 among people 
              with professional exposure to pesticides. Finally, an American study 
              conducted by the team of Alberto Ascherio from Harvard covering 
              a population of 143,325 people followed for several years shows 
              that exposure to pesticides increases the risk of contracting Parkinson’s 
              by 1.7.
              
            French court condemns the agrochemical giant Monsanto 
              for misleading publicity
              The environmental organisation Eaux 
              et Rivieres de Bretagne (ERB) won a complaint against the misleading 
              publicity of Roundup (glyphosate), the herbicide with the highest 
              worldwide sales. According to the ruling of the Lyon Court, Monsanto 
              France will have to pay a fine of 15,000 euro. The distributor of 
              Roundup, Scotts France, was also condemned to pay 15,000 euro. The 
              Court also ordered the publication of the judgement results in the 
              daily newspaper Le Monde and the magazine Maison et Jardin.
            ERB started the legal process in 2001, appalled by the advertisements 
              of Monsanto identifying Roundup as “biodegradable” and 
              “respecting the environment”. These claims were made 
              in 2000 in an aggressive television publicity campaign. ERB successfully 
              proved that glyphosate is present in many rivers in Bretagne and 
              is a product dangerous for the environment and human health. According 
              to the European Commission, products containing glyphosate have 
              to be labelled as “dangerous for the aquatic environment” 
              and “responsible for long-term effects on the environment”.            
            With this misleading publicity, Monsanto was conveying the message 
              that the product was not dangerous and targeting amateur users. 
              But according to ERB, as many as 55% of all rivers in Bretagne are 
              contaminated by glyphosate above levels permitted for human consumption. 
              
             
            Second Risk Reduction Survey by the OECD
              The OECD has published the results of its 2004 questionnaire survey 
              from member states. The survey was meant to identify pesticides 
              risk reduction policies introduced, what worked, and what didn’t, 
              and their costs and benefits during the decade since the first survey 
              in 1994-1995. It focuses on policy tools and approaches used, best 
              practices as well as challenges faced in implementing various policy 
              tools and activities. Only 18 OECD countries responded to the survey: 
              Australia, Canada, Denmark, Germany, Hungary, Ireland, Japan, Korea, 
              the Netherlands, New Zealand, Norway, the Slovak Republic, Slovenia, 
              Sweden, Switzerland, the UK, the US and the EC.
            As usual with the OECD Pesticide Working Group, the focus is on 
              risk, not hazard, reduction, but there is useful information of 
              different regulatory actions in different countries and different 
              approaches. The first section pulls together general results and 
              the appendix gives the individual country reports to the questionnaire. 
              Two of the questions have been suggested by PAN Europe: information 
              on poisonings and protection of vulnerable groups but few countries 
              responded to these. 
            
            Common mixture of pesticides associated with lower 
              sperm count
              There is growing concern that poisoning and other adverse health 
              effects are increasing because organophosphate insecticides are 
              now being used in combination with pyrethroid insecticides. This 
              mix is commonly used to enhance the toxic effects of pyrethroid 
              insecticides on target insects, especially those that have developed 
              resistance to this chemical class.
            The researchers conducted a pilot biomonitoring study in the United 
              States to determine whether men in the reproductive cohort study 
              were being exposed to pesticides environmentally by virtue of frequenting 
              an agricultural setting. 18 randomly selected urine samples collected 
              from male participants of reproductive age were screened for 24 
              parent compounds and metabolites of pesticides and examined the 
              results in relation to sperm concentration. The results showed high 
              prevalence of exposure to organophosphate and pyrethroid pesticides 
              and the preliminary analyses suggested that the higher exposure 
              group had lower sperm concentration. The potential of organophosphorus 
              and pyrethroid mixtures to have enhanced human toxicity needs more 
              research attention. 
            Because pesticides are evaluated on an individual basis, important 
              effects arising from the combination of different substances are 
              missed. Risk assessment of pesticides urgently needs to take these 
              findings into consideration and evaluate common mixtures of pesticides.
              
            Long term low-level exposure to organophosphates linked 
              to neurological impairment
              There are many occupational hazards associated with working in agriculture, 
              including risk of injury and exposure to pesticides. Research examining 
              neurobehavioural effects of pesticide exposure have focused primarily 
              on the acute effects in adults working in agriculture. Organophosphate-poisoned 
              populations have shown a consistent pattern of deficits when compared 
              to a non-exposed or non-poisoned population in measures of motor 
              speed and coordination, sustained attention, and information processing 
              speed. Fewer studies have examined the effect of long-term low-level 
              exposure on nervous system functioning in agricultural workers. 
              Pesticides are thought to pose a considerably higher risk to children 
              than to adults, yet little is known about the extent or magnitude 
              of health problems related to occupational exposure to pesticides 
              in children and adolescents. 
            The present study compared the neurobehavioural performance of 
              US adolescents and adults working in agriculture and examined the 
              impact of years working in agriculture on neurobehavioural performance. 
              One hundred seventy-five Hispanic adolescent and adults completed 
              a neurobehavioural test battery consisting of 10 computer-based 
              tests measuring attention, response speed, coordination and memory. 
              Age, gender, school experience, and years working in agriculture 
              all impacted performance on the neurobehavioural tests. Comparison 
              of adult and adolescents did not reveal decreased neurobehavioural 
              performance in adolescents. On several tests the adolescents performed 
              better than adult counterparts. The adolescents and adults were 
              engaged in comparable agricultural working environments at the time 
              of the neurobehavioural testing. These findings suggest that, at 
              the time of exposure to pesticides, adolescents are not more vulnerable 
              to the effects of working in agriculture. Evidence from this study 
              suggests that cumulative exposure to low levels of pesticides over 
              many years of agricultural work is associated with neurological 
              impairment as measured by the Selective Attention, Symbol-Digit, 
              Reaction Time tests. Experience handling pesticides was also associated 
              with deficits in neurobehavioural performance.
              
            Runoff of pesticides used in urban areas 
              This study establishes an annual watershed budget of pesticide contamination 
              in the Marne River (France) based on detailed enquiries from farmers' 
              organisations, public services and residents and pesticide usage. 
              Results showed that although urban uses were considerably lower 
              (47 tons/yr) than agricultural ones (4300 tons/yr), the proportion 
              of the amounts used transferred to surface water, differs considerably 
              between urban and agricultural environments. Transfer from urban 
              uses was estimated from runoff experiments with different surfaces, 
              including concrete, tarmac, sand and gravel, and grass. Transfer 
              coefficients from agricultural uses were derived from the calibrated 
              value previously obtained from a detailed budget established for 
              atrazine, taking into account the specific adsorption capacity (Koc) 
              and half-life time of each substance used. 
            The calculated annual budget shows a similar contribution by urban 
              pesticides to contamination of the Marne River due to runoff over 
              impervious surfaces as compared to agricultural pesticides used 
              on cultivated soils (about 11 tons/yr in both cases). These estimates 
              are consistent with data available from analytical surveys concerning 
              pesticide occurrence in the rivers of the Paris region.
            These results support the introduction of measures to regulate 
              the use phase of biocides (pesticides for non-agriculture uses) 
              similar to the measures that have been recently proposed under the 
              Thematic Strategy for the Sustainable Use of Pesticides.
             
            Chlorpyriphos negative effects in children’s 
              neurodevelopment
              Inner-city US children exposed in utero to high levels of chlorpyriphos 
              had significantly greater delays in mental and psychomotor development 
              than peers with low prenatal exposure, investigators reported. Children 
              born to mothers who had been exposed to high levels of Dursban (chlorpyrifos) 
              had a fivefold greater risk for delays in psychomotor development, 
              and a nearly 2.5-fold greater risk for delayed mental development.            
            Until it was banned for residential use by the Environmental Protection 
              Agency in 2000, chlorpyriphos was among the most widely used agricultural 
              and indoor pesticides, found in an estimated 20 million American 
              homes. In Europe, it is widely used as a pesticide for agriculture 
              uses and as a biocide in homes and gardens. Chlorpyriphos is an 
              organophosphate, a class of insecticides that can cause both acute 
              and sub-acute toxicity. They work by disrupting acetyl cholinesterase, 
              the enzyme that controls the neurotransmitter acetylcholine, resulting 
              in over-stimulation of nerves and muscles. Organophosphates are 
              absorbed by inhalation, ingestion, and through the skin, and can 
              cause symptoms that include headache, hypersecretion, muscle twitching, 
              nausea, diarrhoea, respiratory depression, seizures and loss of 
              consciousness. 
            In the current analysis, the investigators evaluated the neurotoxicant 
              effects of prenatal exposure to chlorpyriphos in 254 of the children, 
              who are part of an ongoing prospective study through the first three 
              years of their lives. The study measured cognitive and motor development 
              at 12, 24, and 36 months of age using the Bayley Scales of Infant 
              Development and child behaviour at 36 months using the Child Behaviour 
              Checklist. The authors found that children with high exposure, on 
              average scored 6.5 points lower on the Bayley Psychomotor Development 
              Index and 3.3 points lower on the Bayley Mental Development Index 
              at age three, compared with children with lower exposure levels. 
              They also found that the developmental trajectories for psychomotor 
              development index and mental development index scores confirmed 
              that adverse cognitive and psychomotor effects increased over time, 
              and these effects were present in both Dominican and black subjects, 
              which supported the main conclusion of the study.
            In addition, children with high levels of prenatal exposure to 
              the pesticide were significantly more likely than children with 
              low exposure to score in the clinical range on tests for attention 
              problems, attention deficit hyperactivity disorder, and pervasive 
              developmental disorder problems at 3 years of age.
            
            
              3. News from PAN Europe partners
            Highly contaminated fruits and vegetables found by 
              Greenpeace in Germany and Austria
              After analysing pesticides residues in fruits and vegetables, Greenpeace 
              Germany has found several samples to be highly contaminated with 
              acutely toxic pesticides. Two per cent (12 samples) of the 576 fruit 
              and vegetable samples on sale at the leading German and Austrian 
              supermarkets exceed the Acute Reference Dose (ARfD) for children. 
              Children's health is at risk if eating this produce just once. Nine 
              per cent (seven out of 80 samples) of grapes grown by conventional 
              farming methods are also over this warning figure. Lettuce is also 
              affected. Greenpeace reported to the boards of the supermarket chains 
              concerned and to the authorities as having committed an offence 
              by repeatedly marketing food dangerous to health.
            "A 12-kilogramme child eating just ten of these heavily contaminated 
              grapes can already suffer damage to health”, says Manfred 
              Krautter from Greenpeace. Greenpeace is calling on companies and 
              state authorities to make effective controls and take immediate 
              steps to protect consumers and stop the sale of dangerous food. 
              The pesticide contamination of this conventionally-grown produce, 
              which comes from Spain, Italy and Turkey, exceeds the ARfD up to 
              twofold. The produce has been sold at several large supermarket 
              chains in Germany and Austria.
            The World Health Organisation and the German Federal Institute 
              for Risk Assessment (BfR) lay down the ARfD figure. According to 
              a statement by the BfR in November 2005, "exceedance of the 
              ARfD is tangible evidence of possible impairment to human health 
              ... an exceedance of the ARfD [is] from the point of view of protection 
              of consumers' health not acceptable”. 
              
              
            
            This PAN Europe Newsletter was compiled by Sofia 
              Parente
              Contributions are welcome from PAN Europe network members, PURE 
              supporters and individuals.